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Literature summary extracted from
- Alteration of the substrate and inhibitor specificities of blood coagulation factor VIIa: importance of amino acid residue K (1995), Biochemistry, 34, 8701-8707.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.21.21 | K192E | completely ineffective mutant enzyme | Homo sapiens |
| 3.4.21.21 | K192Q | mutant has 44% of the activity compared to the wild-type enzyme | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.21 | Bovine pancreatic trypsin inhibitor | mutant enzyme K192E is poorly inhibited, mutant enzyme K192Q is inhibited more than the wild-type enzyme | Homo sapiens | |
| 3.4.21.21 | tissue factor pathway inhibitor | no inhibition of the mutant enzymes K192E and K192Q | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.21 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.21 | - |
Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.21 | chromozym t-PA + H2O | - |
Homo sapiens | ? | - |
? |  |
| 3.4.21.21 | D-cyclohexylglycyl-L-2-aminobutyryl-L-arginyl-4-nitroanilide + H2O | - |
Homo sapiens | D-cyclohexylglycyl-L-2-aminobutyryl-L-arginine + 4-nitroaniline | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.21 | additional information | - |
additional information | turnover-number of wild-type and mutant enzymes | Homo sapiens |
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